Bio-Integrated Microsystems Group

Principal Investigator: Prof. Wei Ouyang

1. Bioelectronics for precision healthcare


We develop wearable and implantable devices for health monitoring and therapeutic intervention, leveraging diverse sensing modalities, including electrochemical, mechanoacoustic, and optoelectronic sensing, and stimulation modalities such as electrical and pharmacological delivery.


Representative publications († denotes equal contributions, * denotes corresponding authors):

  1. Y. Zhang,* E. Rytkin, L. Zeng, J.U. Kim, L. Tang, H. Zhang, A. Mikhailov, K. Zhao, Y. Wang, L. Ding, X. Lu, A. Lantsova, E. Aprea, G. Jiang, S. Li, S.G. Seo, T. Wang, J. Wang, J. Liu, J. Gu, F. Liu, K. Bailey, Y.F.L. Li, A. Burrell, A. Pfenniger, A. Ardashev, T. Yang, N. Liu, Z. Lv, N.S. Purwanto, Y. Ying, Y. Lu, C. Hoepfner, A. Melisova, J. Gong, J. Jeong, J. Choi, A. Hou, R. Nolander, W. Bai, S.H. Jin, Z. Ma, J.M. Torkelson, Y. Huang,* W. Ouyang,* R.K. Arora,* I. R. Efimov,* and J.A. Rogers,* “Millimetre-scale bioresorbable optoelectronic systems for electrotherapy,” Nature 640, 77–86 (2025).
  2. X. Li, S. Liu, J. Mo, C. Yang, M. Morales, and W. Ouyang,* “Wireless, Multimodal Monitoring of Organ Health Using 3D-Printed, Barbed, Bioresorbable Stretchable Microneedle Sensor Arrays,” under review.
  3. H. Guo,† W. Bai,†* W. Ouyang,† Y. Liu, C. Wu, Y. Xu, Y. Weng, H. Zang, Y. Liu, L. Jacobson, Z. Hu, H.M. Arafa, Q. Yang, D. Lu, S. Li, L. Zhang, X. Xiao, E. Dempsey, N. Ghoreishi-Haack, E.A. Waters, C.R. Haney, A.M. Westman, M.R. MacEwan, M.A. Pet,* J.A. Rogers,* “Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts,” Nat. Commun. 13, 3009 (2022).
  4. H. Jeong,† J.-Y. Yoo,† W. Ouyang,† A. L. J. X. Greane, A. J. Wiebe, I. Huang, Y. J. Lee, J. Y. Lee, J. Kim, X. Ni, S. Kim, H.L. Huynh, I. Zhong, Y.X. Chin, J. Gu, A.M. Johnson, T. Brancaccio, and J.A. Rogers,* “Closed-loop network of skin-interfaced wireless devices for quantifying vocal fatigue and providing user feedback,” Proc. Natl. Acad. Sci. 120, e2219394120 (2023).
  5. X. Ni,† W. Ouyang,† H. Jeong, J.-T. Kim, A. Tzaveils, A. Mirzazadeh, C. Wu, J. Y. Lee, M. Keller, C. K. Mummidisetty, M. Patel, N. Shawen, J. Huang, H. Chen, S. Ravi, J.-K. Chang, K.H. Lee, Y. Wu, F. Lie, Y.J. Kang, J.U. Kim, L.P. Chamorro, A.R. Banks, A. Bharat, A. Jayaraman, S. Xu,* and J.A. Rogers,* “Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients,” Proc. Natl. Acad. Sci. 118 (2021).
  6. J.-T. Kim,† W. Ouyang,† H. Hwang,† H. Jeong,† S. Kang, S. Bose, S. S. Kwak, X. Ni, H. Kim, J. Park, H. Chen, A. Soetikno, J. Kim, S. Xu, L.P. Chamorro,* J.A. Rogers,* “Dynamics of plosive consonants via imaging, computations, and soft electronics,” Proc. Natl. Acad. Sci. 119, e2214164119 (2022).



2. Neural interfaces


We develop devices that enable multimodal, spatiotemporally resolved recording of neuroelectrophysiology and neurochemical dynamics, synchronized with peripheral physiology and behavioral output in freely behaving animals, providing powerful tools for advancing our understanding of the brain.


Representative publications († denotes equal contributions, * denotes corresponding authors):

  1. W. Ouyang,† W. Lu,† Y. Zhang,† Y. Liu, J. U. Kim, H. Shen, Y. Wu, H. Luan, K. Kilner, S. P. Lee, Y. Lu, Y. Yang, J. Wang, Y. Yu, A. Wegener, J. Moreno, Z. Xie, Y. Wu, C. Wu, W. Bai, H. Guo, T.-L. Liu, H. Bai, G. Monti, J. Zhu, S. Madhvapathy, J. Trueb, M. Stanslaski, E. Higbee-Dempsey, II. Stepien, N. Ghoreishi-Haack, C. Haney, Y. Huang, R. Ghaffari, A. Banks, T. Jhou,* C. Good,* J.A. Rogers,* “A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals,” Nat. Biomed. Eng., 1–18 (2023).
  2. W. Ouyang, K.J. Kilner, R.M.P. Xavier, Y. Liu, Y. Lu, S.M. Feller, K.M. Pitts, M. Wu, J. Ausra, I. Jones, Y. Wu, H. Luan, J. Trueb, E.M. Higbee-Dempsey, I. Stepien, N. Ghoreishi-Haack, C.R. Haney, H. Li, Y. Kozorovitskiy, M. Heshmati, A.R. Banks, S.A. Golden,* C.H. Good,* and J.A. Rogers,* “An implantable device for wireless monitoring of diverse physio-behavioral characteristics in freely behaving small animals and interacting groups,”Neuron 112, 1-14 (2024).



3. MEMS and micro/nanofluidics


We study fluid and molecular transport phenomena at the micro- and nanoscale to develop tools for precise biomolecule manipulation, enabling lab-on-a-chip solutions for disease diagnosis.

Representative publications († denotes equal contributions, * denotes corresponding authors):

  1. W. Ouyang, J. Han,* “Universal amplification-free molecular diagnostics by billion-fold hierarchical nanofluidic concentration,” Proc. Natl. Acad. Sci. 116, 16240–16249 (2019).
  2. W. Ouyang, J. Han,* “One‐Step Nucleic Acid Purification and Noise‐Resistant Polymerase Chain Reaction by Electrokinetic Concentration for Ultralow‐Abundance Nucleic Acid Detection,” Angew. Chemie. 132, 11074–11081 (2020).
  3. W. Ouyang, X. Ye, Z. Li,* J. Han,* “Deciphering ion concentration polarization-based electrokinetic molecular concentration at the micro-nanofluidic interface: Theoretical limits and scaling laws,” Nanoscale. 10, 15187–15194 (2018).
  4. W. Ouyang, Z. Li,* J. Han,* “Pressure-modulated selective electrokinetic trapping for direct enrichment, purification, and detection of nucleic acids in human serum,” Anal. Chem. 90, 11366–11375 (2018).
  5. W. Ouyang, S. H. Ko, D. Wu, A. Y. Wang, P. W. Barone, W. S. Hancock, J. Han,* “Microfluidic platform for assessment of therapeutic proteins using molecular charge modulation enhanced electrokinetic concentration assays,” Anal. Chem. 88, 9669–9677 (2016).